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Crisis Centre

Otto Sanchez
MD, PhD

Professor

Associate Dean, Undergraduate Studies and Student Experience

Faculty of Health Sciences

Contact information

Science Building - Room 2008
North Oshawa
2000 Simcoe Street North
Oshawa, ON L1H 7K4

905.721.8668 ext. 2994

otto.sanchez@uoit.ca


Research topics

  • environmental factors of cancer
  • knowledge synthesis and translation in environmental health
  • pathophysiology of cancer

Research and expertise

  • Background and interests

    Research area of specialty:

    • Disparities in cancer, with focus on the role of environmental pollutants in human cancer.
    • Educational use of technology in health sciences, with emphasis on online/hybrid education and use of case studies.
    • Mechanisms of cancer tumorigenesis and metastasis.

    Research background and interests:

    Dr. Sanchez’s cancer research concentrates on systematically evaluating the scientific evidence behind the role of environmental factors in the development and progression of human cancers. It is aimed at the translational implications of this knowledge to public health and the community at large. He co-ordinates the university's Environment and Cancer Working Group.

    Additionally, he maintains collaborations with research groups at Princess Margaret Hospital, studying genetic models of human cancer that allow the identification of novel molecular mechanisms of tumorigenesis and cancer progression. This work has resulted in important contributions in the understanding of the pathophysiology of bone metastasis and human osteosarcoma, among others.

    Given the rich technological infrastructure at the University of Ontario Institute of Technology, his teaching interests focus on:

    • Effective use of educational technology in health sciences.
    • Implementation of blended-learning course formats.
    • Use of case studies to incorporate clinical context through interactive face-to-face and web-based environments. 
  • Publications

    For a comprehensive list of publications, visit PubMed.

    • El Ghamrasni S, Cardoso R, Halaby MJ, Zeegers D, Harding S, Kumareswaran R, Yavorska T, Chami N, Jurisicova A, Sanchez O, Hande MP, Bristow R, Hakem R, Hakem A (2014). Co-operation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression. Oncogene, May 26.
    • LeSage A, Samis J, Hinch R, Longo F, DiGiuseppe M, Goodman W, Percival J, De La Rocha A, Rodrigues A, Raby P, Sanchez O (2014). Pathways from college to university: A social science example from Ontario. College Quarterly 17(1).
    • Sritharan J, Kamaleswaran R, McFarlan K, Lemonde M, George C,Sanchez O (2014). Environmental factors in an Ontario community with disparities in colorectal cancer incidence. Global Journal of Health Science 6(3):175-185.
    • Bohgaki M, Hakem A, Halaby MJ, Bohgaki T, Li Q, Bissey PA, Shloush J, Kislinger T, Sanchez O, Sheng Y, Hakem R (2013). The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover. Cell Death and Differentiation, 20(6):812-822.
    • Halaby MJ, Hakem A, Li L, El Ghamrasni S, Venkatesan S, Hande PM, Sanchez O, Hakem R (2013). Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. Public Library of Science Genetics, 9(1):e1003259.
  • Research collaborators
    • Dr. Razqallah Hakem - Ontario Cancer Institute, Princess Margaret Hospital
    • Dr. Rama Khokha - Ontario Cancer Institute, Princess Margaret Hospital
  • Courses taught

    Courses taught (past and present) at the undergraduate level:

    • Advanced Pathophysiology
    • Pathophysiology I
    • Pathophysiology II
    • Cancer Biology

    Courses taught (past and present) at the graduate level:

    • Environmental Determinants of Health
  • Graduate student research
    • Master of Health Sciences (MHSc) thesis supervisor for Jeavana Sritharan (2010 to 2012) – Investigating The Relationship Between Modifiable Environmental Risk Factors and Incidence of Colorectal Cancer: A Community Based Study.
  • Grants
    • Teaching Innovation Fund, UOIT. Zitzelsberger H and Sanchez O. The Application and Evaluation of Wiki Technology for Online Collaborative Group Projects.
      • 2013 to 2014 (one year), $6,800
    • UOIT and Durham College. Principal Investigators: LeSage, A and Longo, F. Co-applicants: Goodman, B, Percival, J, Samis, J, Sanchez, O, Hinch, R, DiGiuseppe, M, De La Rocha, A, Rodrigues, A and Raby, P. Barriers to Pathway Completion.
      • 2012 to 2013 (one year), $30,000
    • The J.P. Bickell Foundation. Jones Taggart H and Sanchez O. Environmental Toxins and Breast Cancer.
      • 2008 to 2009 (one year), $62,308
    • Natural Sciences and Engineering Research Council of Canada (NSERC). Hung CK, Vogwill V, Yu ESK, Sanchez OH and Stanyon W. Privacy Access Control Enforcement Model for Mobile Ad Hoc Healthcare Services.
      • 2007 to 2009 (two years), $144,000
    • Bell University Laboratories. Hung CK, Stanyon W and Sanchez O. Requirements to Architecture for Health-care Privacy in Ad Hoc Networks (MANETs).
      • 2007-2009 (two years), $50,000
  • Education
    • Master of Science, University of Toronto in Toronto, Ontario, 1990
    • PhD, McMaster University in Hamilton, Ontario, 1997
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